Convenient Dosing with AZILECT

AZILECT Dosage as Monotherapy1

  • AZILECT 1 mg tablets should be taken orally once daily

AZILECT Dosage as an Adjunct to Levodopa1

  • AZILECT 0.5 mg tablets should be taken orally once daily
  • Dose may be increased to 1 mg daily as required for sufficient clinical response
  • A reduction in the levodopa dose may be considered

Patients with mild hepatic impairment1

  • AZILECT 0.5 mg tablets should be taken orally once daily
  • Dose should not exceed 0.5 mg daily
  • AZILECT should not be used in patients with moderate or severe hepatic impairment

AZILECT has not been studied in patients with severe renal impairment. Patients taking ciprofloxacin or other CYP1A2 inhibitors should not exceed a 0.5 mg daily dose. AZILECT can be taken with or without food.

Please see important safety information and complete prescribing information. 


REFERENCE
1. AZILECT Prescribing Information.


 

AZL101023776/101253

 

AZILECT (rasagiline tablets) is indicated for the treatment of the signs and symptoms of idiopathic Parkinson’s Disease (PD) as initial monotherapy and as adjunct therapy to levodopa.

IMPORTANT SAFETY INFORMATION ABOUT AZILECT

Azilect is contraindicated with meperidine; the analgesics tramadol, methadone, and propoxyphene; the antitussive agent dextromethorphan; as well as St. John’s wort and cyclobenzaprine. Azilect is also contraindicated with other MAOIs.

In general, the combination of Azilect and antidepressants should be avoided. Caution should be used when giving Azilect concurrently with CYP1A2 inhibitors such as ciprofloxacin. Patients with moderate to severe hepatic impairment should not take Azilect. The daily dose of Azilect should not exceed 1 mg because of the risks associated with nonselective inhibition of MAO. PD patients are advised to monitor for melanoma frequently and see a dermatologist on a regular basis.

The most common side effects as monotherapy include: flu syndrome, arthralgia, depression, and dyspepsia; and as adjunct to levodopa therapy include: dyskinesia, accidental injury, weight loss, postural hypotension, vomiting, anorexia, arthralgia, abdominal pain, nausea, constipation, dry mouth, rash, abnormal dreams, and fall.

AZL101023762/101241